منابع مشابه
Entropy-driven genome organization.
DNA and RNA polymerases active on bacterial and human genomes in the crowded environment of a cell are modeled as beads spaced along a string. Aggregation of the large polymerizing complexes increases the entropy of the system through an increase in entropy of the many small crowding molecules; this occurs despite the entropic costs of looping the intervening DNA. Results of a quantitative cost...
متن کاملGenome Organization/ Human
The human nuclear genome contains 3000 million base pairs (bp) of DNA, of which only an estimated 3% possess protein-encoding sequences. As shown in Figure 1, the DNA sequences of the eukaryotic genome can be classified into several types, including single-copy protein-encoding genes, DNA that is present in more than one copy (repetitive sequences) and intergenic (spacer) DNA. The most complex ...
متن کاملGenome organization and regulation
The broad-ranging topic of this Minisymposium attracted four presentations describing in vivo and in vitro experimental work and two presentations that primarily addressed theoretical aspects of chro-matin behavior over long and short length scales. Overall, the focus was very much on chromosomes, with presentations addressing chromosome ends (telomeres), centromeres, chromosome segregation , h...
متن کاملNuclear organization and genome function.
Long-range interactions between transcription regulatory elements play an important role in gene activation, epigenetic silencing, and chromatin organization. Transcriptional activation or repression of developmentally regulated genes is often accomplished through tissue-specific chromatin architecture and dynamic localization between active transcription factories and repressive Polycomb bodie...
متن کاملSelf-organization in the genome.
O ne of the most important recent discoveries in the field of genome biology has been the demonstration that genomes are nonrandomly organized in the cell nucleus (1, 2). Examples now abound of chromosomes or genes localizing to a particular location in the nucleus or undergoing positional changes as they became activated or repressed. Much of what we know about how genomes are organized in spa...
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ژورنال
عنوان ژورنال: Nature Methods
سال: 2020
ISSN: 1548-7091,1548-7105
DOI: 10.1038/s41592-020-0893-x